abstract：:Autoimmune hepatitis (AIH) is defined as a chronic liver inflammation with loss of tolerance against hepatocytes. The etiology and pathophysiology of AIH are still poorly understood because reliable animal models are limited. Therefore, we recently introduced a model of experimental murine AIH by a self-limited adenov...

journal_title：Journal of autoimmunity

authors： Hardtke-Wolenski M,Dywicki J,Fischer K,Hapke M,Sievers M,Schlue J,Anderson MS,Taubert R,Noyan F,Manns MP,Jaeckel E

更新日期：2017-03-01 00:00:00

abstract：:Autoimmunity mediated by IgG4 subclass autoantibodies is an expanding field of research. Due to their structural characteristics a key feature of IgG4 antibodies is the ability to exchange Fab-arms with other, unrelated, IgG4 molecules, making the IgG4 molecule potentially monovalent for the specific antigen. However,...

journal_title：Journal of autoimmunity

authors： Koneczny I,Stevens JA,De Rosa A,Huda S,Huijbers MG,Saxena A,Maestri M,Lazaridis K,Zisimopoulou P,Tzartos S,Verschuuren J,van der Maarel SM,van Damme P,De Baets MH,Molenaar PC,Vincent A,Ricciardi R,Martinez-Martinez P,

更新日期：2017-02-01 00:00:00

abstract：:B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

journal_title：Journal of autoimmunity

authors： Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

更新日期：2017-02-01 00:00:00

abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

journal_title：Journal of autoimmunity

authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Immune mediated diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), and inflammatory bowel disease (IBD) commonly affect young and adolescent females. Anti-tumor necrosis factor (TNF)-α agents are increasingly used to treat these conditions, but their safety during pregnancy remains uncl...

journal_title：Journal of autoimmunity

authors： Komaki F,Komaki Y,Micic D,Ido A,Sakuraba A

更新日期：2017-01-01 00:00:00

abstract：:Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully unde...

journal_title：Journal of autoimmunity

authors： Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

更新日期：2017-01-01 00:00:00

abstract：:The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess iodine intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and...

journal_title：Journal of autoimmunity

authors： Xu C,Wu F,Mao C,Wang X,Zheng T,Bu L,Mou X,Zhou Y,Yuan G,Wang S,Xiao Y

更新日期：2016-12-01 00:00:00

abstract：:Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sjögren's syndrome patients (SS)-patients show signs of inflammation and altered proteostasis, associated with low IRE1α/XBP-1 pathway a...

journal_title：Journal of autoimmunity

authors： Barrera MJ,Aguilera S,Castro I,Cortés J,Bahamondes V,Quest AFG,Molina C,González S,Hermoso M,Urzúa U,Leyton C,González MJ

更新日期：2016-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a poorly understood preclinical stage of immune dysregulation and symptom accrual. Accumulation of antinuclear autoantibody (ANA) specificities is a hallmark of impending clinical disease. Yet, many ANA-positive individuals remain healthy, suggest...

journal_title：Journal of autoimmunity

authors： Lu R,Munroe ME,Guthridge JM,Bean KM,Fife DA,Chen H,Slight-Webb SR,Keith MP,Harley JB,James JA

更新日期：2016-11-01 00:00:00

abstract：:Viruses, bacteria and other infectious pathogens are the major postulated environmental triggers of autoimmunity. In the present nation-wide study we describe the association between infections and 29 autoimmune diseases. We used the Danish Civil Registration System to identify 4.5 million persons born between 1945 an...

journal_title：Journal of autoimmunity

authors： Nielsen PR,Kragstrup TW,Deleuran BW,Benros ME

更新日期：2016-11-01 00:00:00

abstract：:The significant decrease in mortality rates worldwide, the increased proportion of patients achieving a durable remission, and the recent approval of a new drug after several decades are encouraging advances in the tangled history of systemic lupus erythematosus (SLE). However, when data are observed more closely, the...

journal_title：Journal of autoimmunity

authors： Doria A,Gershwin ME,Selmi C

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Sicca symptoms occur in around 30% of rheumatoid arthritis (RA) patients. Herein, we examined the characteristics of RA patients bearing sicca symptomatology (RA-sicca) with a special focus on the immunohistopathological features of their labial minor salivary gland (LMSG) biopsies. METHODS:Our cohort inclu...

journal_title：Journal of autoimmunity

authors： Fragoulis GE,Fragkioudaki S,Reilly JH,Kerr SC,McInnes IB,Moutsopoulos HM

更新日期：2016-09-01 00:00:00

abstract：:Autoimmune diseases affect up to 10% of the world's population, and approximately 80% of those affected are female. The majority of autoimmune diseases occur more commonly in females, although some are more frequent in males, while others show no bias by sex. The mechanisms leading to sex biased disease prevalence are...

journal_title：Journal of autoimmunity

authors： Chiaroni-Clarke RC,Munro JE,Ellis JA

更新日期：2016-05-01 00:00:00

abstract：:Promiscuous expression of a plethora of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for central tolerance. This promiscuous gene expression (pGE) is characterized by inclusion of a broad range of TRAs and by its mosaic expression patterns, i.e. each antigen is only expre...

journal_title：Journal of autoimmunity

authors： Rattay K,Meyer HV,Herrmann C,Brors B,Kyewski B

更新日期：2016-02-01 00:00:00

abstract：:Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing beta cells. The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environme...

journal_title：Journal of autoimmunity

authors： Pearson JA,Wong FS,Wen L

更新日期：2016-01-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by both genetic and environmental factors. Twin and family studies suggest a substantial role for genetic factors in the predispositio...

journal_title：Journal of autoimmunity

authors： Hersh AO,Prahalad S

更新日期：2015-11-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APC) with significant phenotypic heterogeneity and functional plasticity. DCs play crucial roles in initiating effective adaptive immune responses for elimination of invading pathogens and also in inducing immune tolerance toward harmless components to m...

journal_title：Journal of autoimmunity

authors： Liu J,Cao X

更新日期：2015-09-01 00:00:00

abstract：:Following the mass vaccinations against pandemic influenza A/H1N1 virus in 2009, a sudden increase in juvenile onset narcolepsy with cataplexy (NC) was detected in several European countries where AS03-adjuvanted Pandemrix vaccine had been used. NC is a chronic neurological disorder characterized by excessive daytime ...

journal_title：Journal of autoimmunity

authors： Saariaho AH,Vuorela A,Freitag TL,Pizza F,Plazzi G,Partinen M,Vaarala O,Meri S

更新日期：2015-09-01 00:00:00

abstract：:Primary warm autoimmune hemolytic anemia (wAIHA) is a rare autoimmune disease in which red blood cells are eliminated by IgG autoantibodies. We analyzed the antibody-secreting cells in the spleen and the peripheral blood of wAIHA patients in various contexts of treatment. Plasmablasts were observed in peripheral blood...

journal_title：Journal of autoimmunity

authors： Mahévas M,Michel M,Vingert B,Moroch J,Boutboul D,Audia S,Cagnard N,Ripa J,Menard C,Tarte K,Mégret J,Le Gallou S,Patin P,Thai L,Galicier L,Bonnotte B,Godeau B,Noizat-Pirenne F,Weill JC,Reynaud CA

更新日期：2015-08-01 00:00:00

abstract：:Systemic lupus erythematosus is a multi-system disease characterized by wide-spread DNA methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome-wide DNA methylation changes in naïve CD4+ T cells were compared between two sets of lupus patients with and without a history of renal inv...

journal_title：Journal of autoimmunity

authors： Coit P,Renauer P,Jeffries MA,Merrill JT,McCune WJ,Maksimowicz-McKinnon K,Sawalha AH

更新日期：2015-07-01 00:00:00

abstract：:Neuropsychiatric disease is one of the most common manifestations of human systemic lupus erythematosus, but the mechanisms remain poorly understood. In human brain microvascular endothelial cells in vitro, TNF-like weak inducer of apoptosis (TWEAK) decreases tight junction ZO-1 expression and increases the permeabili...

journal_title：Journal of autoimmunity

authors： Wen J,Doerner J,Weidenheim K,Xia Y,Stock A,Michaelson JS,Baruch K,Deczkowska A,Gulinello M,Schwartz M,Burkly LC,Putterman C

更新日期：2015-06-01 00:00:00

abstract：:The Diffuse Infiltrative Lymphocytosis Syndrome (DILS) is a rare multisystemic syndrome described in HIV-infected patients. It is characterised by CD8(+) T-cell lymphocytosis associated with a CD8(+) T-cell infiltration of multiple organs. DILS is usually seen in uncontrolled or untreated HIV infection but can also ma...

journal_title：Journal of autoimmunity

authors： Ghrenassia E,Martis N,Boyer J,Burel-Vandenbos F,Mekinian A,Coppo P

更新日期：2015-05-01 00:00:00

abstract：:Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression has long been the only therapeutic option, activating/expanding Tregs may achieve the same objective without the toxicity of immunosuppress...

journal_title：Journal of autoimmunity

authors： Rosenzwajg M,Churlaud G,Mallone R,Six A,Dérian N,Chaara W,Lorenzon R,Long SA,Buckner JH,Afonso G,Pham HP,Hartemann A,Yu A,Pugliese A,Malek TR,Klatzmann D

更新日期：2015-04-01 00:00:00

abstract：:Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD prote...

journal_title：Journal of autoimmunity

authors： Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

更新日期：2015-02-01 00:00:00

abstract：:Improved clinical findings of inflammatory bowel disease (IBD) upon treatment with helminthes and their ova were proven in animal models of IBD and in human clinical studies. The immunomodulatory properties of several helminthes were attributed to the phosphorylcholine (PC) molecule. We assessed the therapeutic potent...

journal_title：Journal of autoimmunity

authors： Ben-Ami Shor D,Bashi T,Lachnish J,Fridkin M,Bizzaro G,Barshak I,Blank M,Shoenfeld Y

更新日期：2015-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contri...

journal_title：Journal of autoimmunity

authors： François A,Gombault A,Villeret B,Alsaleh G,Fanny M,Gasse P,Adam SM,Crestani B,Sibilia J,Schneider P,Bahram S,Quesniaux V,Ryffel B,Wachsmann D,Gottenberg JE,Couillin I

更新日期：2015-01-01 00:00:00

abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

journal_title：Journal of autoimmunity

authors： García-Muñoz R,Feliu J,Llorente L

更新日期：2015-01-01 00:00:00

abstract：:Immune cell infiltration to the brain's territory was considered for decades to reflect a pathological process in which immune cells attack the central nervous system (CNS); such a process is observed in the inflammatory autoimmune disease, multiple sclerosis (MS). As neuroinflammatory processes within the CNS parench...

journal_title：Journal of autoimmunity

authors： Schwartz M,Baruch K

更新日期：2014-11-01 00:00:00

abstract：:Myasthenia gravis (MG) is a prototypical antibody-mediated disease characterized by muscle weakness and fatigability. Serum antibodies to the acetylcholine receptor and muscle-specific tyrosine kinase receptor (MuSK) are found in about 85% and 8% of patients respectively. We have previously shown that more than 70% of...

journal_title：Journal of autoimmunity

authors： Marino M,Maiuri MT,Di Sante G,Scuderi F,La Carpia F,Trakas N,Provenzano C,Zisimopoulou P,Ria F,Tzartos SJ,Evoli A,Bartoccioni E

更新日期：2014-08-01 00:00:00

abstract：:Lupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secretin...

journal_title：Journal of autoimmunity

authors： Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S

更新日期：2014-05-01 00:00:00

abstract：:A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

journal_title：Journal of autoimmunity

authors： Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

更新日期：2014-05-01 00:00:00

abstract：:B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to determine whether dynamic changes in combinations of serological measures of B-cell activatio...

journal_title：Journal of autoimmunity

authors： Cambridge G,Perry HC,Nogueira L,Serre G,Parsons HM,De La Torre I,Dickson MC,Leandro MJ,Edwards JC

更新日期：2014-05-01 00:00:00

abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

journal_title：Journal of autoimmunity

authors： Chang C

更新日期：2014-02-01 00:00:00

abstract：:Lupus erythematosus (LE) is an inflammatory connective tissue disease of generalized autoimmunity characterized by pathogenic autoantibodies and immune complexes, attributed to loss of immune tolerance. Cutaneous involvement, which appears in the majority of patients with the disease, can present as LE-specific or LE-...

journal_title：Journal of autoimmunity

authors： Kuhn A,Landmann A

更新日期：2014-02-01 00:00:00

abstract：:Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now e...

journal_title：Journal of autoimmunity

authors： Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria A

更新日期：2014-02-01 00:00:00

abstract：:Polymyositis is classified as a separate entity among idiopathic inflammatory myopathies but it is considered as the least common since it is an exclusion diagnosis. This myopathy usually presents with subacute-chronic symmetric proximal limb weakness, although some extramuscular manifestations are common. Creatine ki...

journal_title：Journal of autoimmunity

authors： Milisenda JC,Selva-O'Callaghan A,Grau JM

更新日期：2014-02-01 00:00:00

abstract：:Polymyalgia rheumatica is the most common inflammatory rheumatic disease of the elderly, and shares many pathogenetic and epidemiological features with giant cell arteritis. The typical symptoms are bilateral aching of the shoulder girdle, associated with morning stiffness. The neck and hip girdle may also be involved...

journal_title：Journal of autoimmunity

authors： Nesher G

更新日期：2014-02-01 00:00:00

abstract：:Epidemiology is expected to provide important clues to our understanding of the enigmatic etiopathogenesis of primary biliary cirrhosis (PBC). First, a systematic review of population based studies indicated a wide range in the yearly incidence (0.33-5.8/100.000) and point prevalence (1.91-40.2/100.000) rates. Though ...

journal_title：Journal of autoimmunity

authors： Podda M,Selmi C,Lleo A,Moroni L,Invernizzi P

更新日期：2013-10-01 00:00:00

abstract：:Natural autoantibodies (autoNAb) recognize self antigens and are an important component of the immune system, as species ranging from invertebrates to vertebrates have polyreactive IgM NAbs. In higher vertebrates, different polyreactive autoNAbs isotypes are also frequently encountered and autopolyreactive IgG NAbs ar...

journal_title：Journal of autoimmunity

authors： Avrameas S,Selmi C

更新日期：2013-03-01 00:00:00

abstract：:Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver diseases. Among these, there is limited agreement on the definitions and treatment of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) overlap syndromes, we evaluated a large series of consecutive patients with PBC (...

journal_title：Journal of autoimmunity

authors： Wang Q,Selmi C,Zhou X,Qiu D,Li Z,Miao Q,Chen X,Wang J,Krawitt EL,Gershwin ME,Han Y,Ma X

更新日期：2013-03-01 00:00:00